Oxidation Inhibits Iron-Induced Blood Coagulation
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منابع مشابه
Oxidation Inhibits Iron-Induced Blood Coagulation
Blood coagulation under physiological conditions is activated by thrombin, which converts soluble plasma fibrinogen (FBG) into an insoluble clot. The structure of the enzymatically-generated clot is very characteristic being composed of thick fibrin fibers susceptible to the fibrinolytic degradation. However, in chronic degenerative diseases, such as atherosclerosis, diabetes mellitus, cancer, ...
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7 HILE STUDYING acute iron intoxication in dogs, Reissmann and his associates14 noticed that just prior to death in dogs no anticoagulant was necessary for collecting blood for various studies. Intestinal bleeding was observed in some experimental animals. Smith, Jones, and Cochran4 reported that in a fatal case of ferrous iron intoxication the heart’s blood remained unclotted for five hours af...
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Lidocaine in the epidural space, through inhibitory effects upon coagulation, may contribute to inefficacy of epidural autologous blood patch (EBP). This study was undertaken to evaluate the effect of achievable epidural concentrations of lidocaine on blood coagulation as a step in testing this hypothesis. Ex vivo blood coagulation using whole blood (n = 20) was studied with computerized thromb...
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Previous work from our laboratory demonstrated that pyridoxal isonicotinoyl hydrazone (PIH) has in vitro antioxidant activity against iron plus ascorbate-induced 2-deoxyribose degradation due to its ability to chelate iron; the resulting Fe(III)-PIH(2) complex is supposedly unable to catalyze oxyradical formation. A putative step in the antioxidant action of PIH is the inhibition of Fe(III)-med...
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Iron overload can increase cellular oxidative stress levels due to formation of reactive oxygen species (ROS); untreated, it can be extremely destructive to organs and fatal to patients. Since elevated oxidative stress levels are inherent to the condition in such patients, oxidation-induced degradable nanogels for iron chelation were rationally designed by simultaneously polymerizing oxidation-...
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ژورنال
عنوان ژورنال: Current Drug Targets
سال: 2013
ISSN: 1389-4501
DOI: 10.2174/138945013804806541